منابع مشابه
Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor.
Genes of interest can be targeted specifically to respiratory epithelial cells in intact animals with high efficiency by exploiting the receptor-mediated endocytosis of the polymeric immunoglobulin receptor. A DNA carrier, consisting of the Fab portion of polyclonal antibodies raised against rat secretory component covalently linked to poly-L-lysine, was used to introduce plasmids containing di...
متن کاملSpecific genetic modifications of domestic animals by gene targeting and animal cloning
The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large livestock species until the successful creation of the first mammalian clone "Dolly" the sheep. The combination of the technologies for gene targeting of somatic cells with those of animal cloni...
متن کاملFrom Gene Targeting to Genome Editing: Transgenic animals applications and beyond.
Genome modification technologies are powerful tools for molecular biology and related areas. Advances in animal transgenesis and genome editing technologies during the past three decades allowed systematic interrogation of gene function that can help model how the genome influences cellular physiology. Genetic engineering via homologous recombination (HR) has been the standard method to modify ...
متن کاملHow close are we to implementing gene targeting in animals other than the mouse?
T paper by Kubota et al. in this issue of PNAS (1) describes several significant contributions that bring us much closer to extending ‘‘gene targeting’’ to mammalian species other than the mouse. Gene targeting now provides the means for creating new strains of mice with mutations in virtually any gene. First, the desired mutation is introduced into a cloned copy of the chosen gene by standard ...
متن کاملPrevalence of recR gene in Campylobacter spp. isolated from domestic animals and water
Although, many genes are involved in pathogenesis of Campylobacter, racR gene considered the main gene for Campylobacter pathogenicity in humans. The purpose of this study was determined the prevalence of recR gene in Campylobacter spp. isolated from domestic animals and water. To perform the study 392 fecal and water samples were collected from poultry(182), cow(141), sheep and goat(41) and w...
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ژورنال
عنوان ژورنال: Nippon Nōgeikagaku Kaishi
سال: 1996
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.70.907